"Aging-associated modification of intestinal homeostasis and barrier function: Role of microbiota, iNOS and innate immunity"

Project of the DFG-Priority programm 1656: Intestinal microbiota – a microbial ecosystem at the edge between immune homeostasis and inflammation


Project of the DFG-Priority programm 1656

 

The aim of the present project is to (1) delineate at what age modifications of intestinal homeostasis and barrier function set in and if these changes are associated with alterations of intestinal microbiota composition, and (2) determine the role of NO-synthesis through iNOS in aging-associated modifications of intestinal microbiota composition and barrier function. Herein, we will especially focus on the role of dietary composition and energy bioavailability as well as identification of novel targeting strategies to prevent aging-associated alterations of intestinal microbiota composition and barrier function.

 

 

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