"Effect of oral supplementation with arginine, citrulline or glutamine on the development and proceeding of non-alcoholic fatty liver disease (NAFLD): Role of sex and age"

funded by Deutsche Forschungsgemeinschaft (DFG)


 

NAFLD is one of the most common liver diseases worldwide. Besides lifestyle interventions frequently afflicted with high relapse rates, therapeutic and preventive options are still rare. Studies show that increased translocation of bacterial endotoxins and an activation of toll-like receptor signaling cascade is associated with development of NAFLD. Results from our own group could demonstrate that an oral supplementation of amino acids like arginine, citrulline or glutamine protects mice from development of NAFLD. Therefore the aim of this project is to determine if amino acids also possess therapeutic effect of NAFLD and if so to clarify molecular mechanisms involved.

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