Microbiota and epigenetic regulation of inflammatory mediators

Autor(en)
Marlene Remely, Heidrun Karlic, Irene Rebhan, Martina Greunz, Alexander G. Haslberger
Abstrakt

Bacteria and bacterial derived metabolites are known to influence the host epigenetic regulation patterns such as DNA methylation and histone modifications, thus altering the expression of critical genes in pathologic processes, for example in metabolic syndrome. Fermentation end products, especially butyrate and LPS (lipopolysaccharides), the latter being cell-wall components of gram-negative bacteria, have been suggested as bioactive metabolites influencing epigenetic modifications by directly influencing enzymes catalyzing epigenetic modifications, by altering the availability of substrates, or by interactions with receptors. Thus, identification and quantification of gut microbiota via molecular based methods are of importance to address different epigenetic patterns and gene expression. We discuss methods for microbiota, epigenetic methylation, and expression analysis of our own research which will have a role in future studies.

Organisation(en)
Department für Ernährungswissenschaften
Externe Organisation(en)
Hanusch Krankenhaus
Seiten
115-134
Anzahl der Seiten
20
DOI
https://doi.org/10.1007/978-1-4939-6743-8_8
Publikationsdatum
2017
Peer-reviewed
Ja
ÖFOS 2012
303020 Medizinische Mikrobiologie
Schlagwörter
ASJC Scopus Sachgebiete
Molecular Medicine, Pharmacology, Toxicology and Pharmaceutics(all), Pharmacology (medical)
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/microbiota-and-epigenetic-regulation-of-inflammatory-mediators(6ed8a4a1-385d-47e1-bcc5-3bbde371d51d).html