Bacterial ghosts

Untertitel:Non-living candidate vaccines
Autoren:Szostak, M.P.; Hensel, A.; Eko, F.O. (Universität Wien); Klein, R.; Auer, T. (Universität Wien); Mader, H.; Haslberger, A.; Bunka, S. (Veterinärmedizinische Universität Wien); Wanner, G. (Ludwig-Maximilians-Universität München); Lubitz, W.
Abstrakt:Bacterial (recombinant) ghosts, derived from human or animal pathogens, are proposed as nonliving candidate vaccines and represent an alternative to heat or chemically inactivated bacteria. In bacterial ghosts, foreign proteins are inserted into the inner membrane via specific N-, C- or N- and C-terminal anchor sequences prior to lysis. Intraperitoneal, subcutaneous or intramuscular applications of bacterial ghosts in experimental animals induced specific humoral and cellular immune responses against bacterial and viral components.
Sprache:Englisch
Anzahl der Seiten:10
Publikationsdatum:26.1.1996
Journaltitel:Journal of Biotechnology
Volume:44
Nummer:1-3
Seiten:161-170
Peer reviewed:true
Links:
Digital Object Identifier (DOI):http://dx.doi.org/10.1016/0168-1656(95)00123-9
Publikationstyp:Artikel
Portal:https://ucris.univie.ac.at/portal/en/publications/bacterial-ghosts(011294a6-7d00-4cb3-8bb3-b14f00ec02bc).html