The microbial epigenome in metabolic syndrome

Autoren:Remely, Marlene; Haslberger, Alexander G

Dietary habits, lifestyle, medication, and food additives affect the composition and functions of the GI microbiota. Metabolic syndrome is already known to be associated with an aberrant gut microbiota affecting systemic low-grade inflammation, which is also outlined by differing epigenetic patterns. Thus, structural changes and compositional evaluation of gut microbial differences affecting epigenetic patterns in metabolic syndrome are of research interest. In the present review we focus on the disparities in the gut microbiota composition of metabolic syndrome and the resulting aberrant profile of bioactive microbial metabolites known to affect epigenetic modifications such as G-protein coupled receptors and inflammatory pathways.

Journaltitel:Molecular aspects of medicine
Peer reviewed:true
Digital Object Identifier (DOI):
Bibliographische Notiz:Copyright © 2016 Elsevier Ltd. All rights reserved.