Personalized nutrition and classification of metabolic types based on genetics, epigenetics and gut microbiota

Autoren:Lilja, Stephanie; Gessner, Diana Saskia Franziska; Schnitzler, christina (TCM Ernährungsberatung Christina Schnitzler); Stephanou-Rieser, Nicola; Nichterl, Claudia (essen:z ernährung + beratung e.U.); Pointner, Angelika; Tomeva, Elena; Remely, Marlene; Haslberger, Alexander
Abstrakt:Humans vary in their need and response to diet. Genetic dispositions,such as single nucleotide polymorphisms (SNPs) arefrequently used for clustering consumers in metabolic types(metabotypes), according to individual characteristics of energyextraction from food or risk for metabolic diseases. Results arethen used for individualized concepts for weight managementor weight loss. However, SNPs explain only a minor part of metabolicvariability whereas epigenetic regulation of metabolicenzymes, GI microbiota and lifestyle are of ample importance.In a pilot study enrolling 37participants under nutritional advicewe analyzed results from a panel of SNPs, epigenetic markersand microbiota as well as food frequency questionnaires. Theresults of this study clearly indicate that epigenetic and microbiotamarkers need to be integrated in the definition of metabotypes.Such improved metabotypes may then enable animproved guidance for a personalized nutrition.
Journaltitel:Journal für Ernährungsmedizin (JEM)
Peer reviewed:true