Mediterranean dietary pattern, inflammation and endothelial function

Untertitel:A systematic review and meta-analysis of intervention trials
Autoren:Schwingshackl, L. (Universität Wien); Hoffmann, Georg
Abstrakt:Background: High adherence to a Mediterranean diet (MD) is associated with reduced all-cause and cardiovascular mortality risk. To our knowledge, there is no systematic review and meta-analysis of randomized controlled trials that has compared the effects of an MD on outcomes of endothelial function and inflammation. Methods and results: Literature search was performed using the electronic databases MEDLINE, EMBASE, and the Cochrane Trial Register. Inclusion criteria were: randomized controlled trials, 19 + years of age, and minimum intervention period of 12 weeks. Study specific weighted mean differences (WMD) were pooled using a random effect model. Seventeen trials including 2300 subjects met the objectives. MD regimens resulted in a significantly more pronounced increase in flow mediated dilatation [WMD: 1.86%, 95% CI 0.23 to 3.48, p = 0.02; I-2 = 43%], and adiponectin [WMD: 1.69 mu g/ml, 95% CI 0.27 to 3.11, p = 0.02; I-2 = 78%], while high-sensitive C reactive protein [WMD: -0.98 mg/l, 95% CI -1.48 to -0.49, p <0.0001; I-2 = 91%], interleukin-6 [WMD: -0.42 pg/ml, 95% CI -0.73 to -0.11, p = 0.008; I-2 = 81%], and intracellular adhesion molecule-1 [WMD: -23.73 ng/ml, 95% CI -41.24 to -6.22 p = 0.008; I-2 = 34%] turned out to be significantly more decreased. Conclusion: The results of the present meta-analysis provide evidence that an MD decreases inflammation and improves endothelial function. (C) 2014 Elsevier B. V. All rights reserved.
Sprache:Englisch
Anzahl der Seiten:11
Publikationsdatum:9.2014
Journaltitel:Nutrition, Metabolism & Cardiovascular Diseases
Volume:24
Nummer:9
Seiten:929-939
Peer reviewed:true
Links:
Digital Object Identifier (DOI):http://dx.doi.org/10.1016/j.numecd.2014.03.003
Publikationstyp:Artikel
Portal:https://ucris.univie.ac.at/portal/en/publications/mediterranean-dietary-pattern-inflammation-and-endothelial-function(5340fae7-a3fb-4601-bfc4-46bfd9c24945).html