Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity – implications for improved metabolic health

Autor(en)

Nazlisadat Seyed Khoei, Annemarie Grindel, Marlies Wallner, Christine Mölzer, Daniel Doberer, Rodrig Marculescu, Andrew Bulmer, Karl-Heinz Wagner

Abstrakt

Background and aims: Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile. Methods: Our study considered GS and age-/gender-matched healthy controls (n = 248). Additionally, obese female type 2 diabetic patients (DM2) (n = 26) were included as a “disease control group”. Results: BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0.001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (≥35 years) had significantly reduced anthropometric data and improved lipid profile. Conclusions: Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.

Organisation(en)

Department für Ernährungswissenschaften, Forschungsplattform Active Ageing

Externe Organisation(en)

Medizinische Universität Wien, Fachhochschule Joanneum, University of Aberdeen, Griffith University

Journal

Atherosclerosis

Band

269

Seiten

306–311

Anzahl der Seiten

6

ISSN

0021-9150

DOI

https://doi.org/10.1016/j.atherosclerosis.2017.12.021

Publikationsdatum

12-2017

Peer-reviewed

Ja

ÖFOS 2012

303026 Public Health

Schlagwörter

ASJC Scopus Sachgebiete

Cardiology and Cardiovascular Medicine

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/mild-hyperbilirubinaemia-as-an-endogenous-mitigator-of-overweight-and-obesity--implications-for-improved-metabolic-health(9274a5ef-a64c-4239-a0ff-0e1496cb7f66).html