Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

Autoren:Wallner, Marlies; Marculescu, Rodrig (Medizinische Universität Wien); Doberer, Daniel (Medizinische Universität Wien); Wolzt, Michael (Medizinische Universität Wien); Wagner, Oswald (Medizinische Universität Wien); Vitek, Libor (Charles University Prague); Bulmer, Andrew C (Griffith University); Wagner, Karl-Heinz
Abstrakt:Recent epidemiological and clinical data show protection from CVD (cardiovascular disease), all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only in part to this protection. Therefore we investigated whether mildly elevated circulating UCB (unconjugated bilirubin) is associated with altered lipid metabolism. The study was performed on GS and age- and gender-matched healthy subjects (n=59 per group). Full lipoprotein profile, TAG (triacylglycerols), Apo (apolipoprotein)-A1, Apo-B, lipoprotein(a), the subfractions of LDL (low-density lipoprotein) and selected pro-inflammatory mediators were analysed. A hyperbilirubinaemic rodent model (Gunn rats, n=40) was investigated to further support the presented human data. GS subjects had significantly (P
Anzahl der Seiten:8
Journaltitel:Clinical Science: an international journal of translational science and medicine
Peer reviewed:true
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