Influence of Energy Balance and Glycemic Index on Metabolic Endotoxemia in Healthy Men

Autoren:Breusing, Nicolle (Universität Hohenheim); Lagerpusch, Merit (Universität Hohenheim); Engstler, Anna Janina (Friedrich-Schiller-Universität Jena); Bergheim, Ina (Friedrich-Schiller-Universität Jena); Müller, Manfred James (Christian-Albrechts-Universität zu Kiel); Bosy-Westphal, Anja (Universität Hohenheim)
Abstrakt:OBJECTIVE: Overfeeding with a high-fat and/or high-carbohydrate (CHO) diet is known to increase plasma concentrations of endotoxin (lipopolysaccharide [LPS]) that may lead to metabolic disturbances like insulin resistance. The impact of CHO quality (i.e., the glycemic index [GI]) independent of fat intake on metabolic endotoxemia remains unclear. In the present study, the effects of changes in energy balance and GI on plasma endotoxin were studied. METHODS: Fifteen healthy young men overconsumed diets containing 65% CHO and 20% fat for 1 week (OF; +50% of energy requirement) followed by 3 weeks of caloric restriction (CR; -50% of energy requirement) and were then randomized to 2 weeks hypercaloric refeeding (RF, +50% of energy requirement) with either a low- or high-GI (40 vs 74) diet. RESULTS: During OF, subjects gained 1.9 ± 0.7 kg body weight (+0.6 ± 0.8% fat mass) followed by a weight loss of 6.1 ± 0.8 kg (-2.0 ± 0.6% fat mass) and weight regain of 4.0 ± 0.6 kg (0.9 ± 0.8% fat mass). Fasting insulin and homeostasis model assessment-insulin resistance (HOMAIR) increased with OF and RF and decreased with CR, MatsudaISI decreased by 37% after RF (all p < 0.05). Endotoxin significantly increased by 30.8% with OF and by 24.7% with RF (both p < 0.05), whereas CR normalized endotoxin levels. No difference in endotoxin levels was observed between refeeding a hypercaloric high- or low-GI diet. Changes in endotoxin levels with RF were not related to changes in insulin sensitivity. CONCLUSION: A hypercaloric diet (OF and RF) increased plasma endotoxin irrespective of GI, whereas a negative energy balance did not reduce endotoxemia. Impaired insulin sensitivity with hypercaloric refeeding on a high-GI diet was not explained by metabolic endotoxemia.
Sprache:Englisch
Publikationsdatum:6.1.2017
Journaltitel:Journal of the American College of Nutrition
Volume:Vol.36
Nummer:2017-Issue 1
Peer reviewed:true
Links:
Digital Object Identifier (DOI):http://dx.doi.org/https://doi.org/10.1080/07315724.2016.1156036
Publikationstyp:Artikel
Portal:https://ucris.univie.ac.at/portal/en/publications/influence-of-energy-balance-and-glycemic-index-on-metabolic-endotoxemia-in-healthy-men(a7b4c58e-6782-4aeb-b470-cf9d8805c389).html