Therapeutic perspectives of epigenetically active nutrients

Autor(en)

M. Remely, L. Lovrecic, A. L. de la Garza, L. Migliore, B. Peterlin, F. I. Milagro, A. J. Martinez, A. G. Haslberger

Abstrakt

Many nutrients are known for a wide range of activities in prevention and alleviation of various diseases. Recently, their
potential role in regulating human health through effects on epigenetics has become evident, although specific mechanisms
are still unclear. Thus, nutriepigenetics/nutriepigenomics has emerged as a new and promising field in current epigenetics
research in the past few years. In particular, polyphenols, as part of the central dynamic interaction between the genome and
the environment with specificity at physiological concentrations, are well known to affect mechanisms underlying human
health. This review summarizes the effects of dietary compounds on epigenetic mechanisms in the regulation of gene
expression including expression of enzymes and other molecules responsible for drug absorption, distribution, metabolism
and excretion in cancer, metabolic syndrome, neurodegenerative disorders and hormonal dysfunction.

Organisation(en)

Department für Ernährungswissenschaften, Department für Evolutionäre Anthropologie

Externe Organisation(en)

Università degli Studi di Pisa, University of Ljubljana, Universidad de Navarra, Universidad Carlos III de Madrid

Journal

British Journal of Pharmacology

Band

172

Seiten

2756-2768

Anzahl der Seiten

13

ISSN

0007-1188

DOI

https://doi.org/10.1111/bph.12854

Publikationsdatum

06-2015

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Pharmacology

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/therapeutic-perspectives-of-epigenetically-active-nutrients(17bab971-c55a-4490-bcc7-a33c347e9573).html