Influence of endotoxin on the distribution of cephalosporins in rabbits

Autor(en)
U Ganzinger, A Haslberger, H Schiel, R Omilian-Rosso, E Schütze
Abstrakt

The concentration: time courses of six different cephalosporins were studied in serum and interstitial fluid from issue cages after intravenous injection in normal and endotoxaemic rabbits. Circulatory and metabolic changes induced by endotoxin were similar to the altered organ function observed in patients with septicaemia. A significant shift of drug fractions, increase in the volume of distribution and prolonged mean residence times were observed in this model with ceftazidime, ceftriaxone and CPW 86-363, and were the result of specific changes in the peripheral compartment. The opposite findings were observed with cefotaxime, while latamoxef and cefoperazone resulted in no changes.

Organisation(en)
Department für Ernährungswissenschaften
Journal
Journal of Antimicrobial Chemotherapy
Band
17
Seiten
785-93
Anzahl der Seiten
9
ISSN
0305-7453
Publikationsdatum
06-1986
Peer-reviewed
Ja
ÖFOS 2012
302030 Innere Medizin
Schlagwörter
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/influence-of-endotoxin-on-the-distribution-of-cephalosporins-in-rabbits(62f97663-56ce-4133-907b-0885df65b40b).html