The role of microbiota in depression - A Brief review
- Autor(en)
- Bojan Zalar, Alexander Haslberger, Borut Peterlin
- Abstrakt
The microbiota-gut-brain axis is a bidirectional homeostatic route of communication between both of the organs direct via receptors of the CNS or via epigenetic mechanisms of divers metabolites e.g. SCFA, GABA, ß-hydroxybutyrate. Thus, a modulation of gut microbiota via nutrition, lifestyle etc. might be effective for emotional status and depressive disorders. The dietary composition has an influence on gut microbiota composition, microbial metabolite profile and the according consequences on emotional status and depression within a system biologic approach. There are changes in gut microbiota composition and gut microbial profile (butyrate, GABA, ß-hydroxybutyrate) effecting epigenetic regulation (histone acetylation, DNA methylation) and gene expression of receptors and mediators (SLC6A4, BDNF, GABA, GPRs) involved in depressive disorders.
- Organisation(en)
- Department für Ernährungswissenschaften
- Externe Organisation(en)
- University Psychiatric Clinic Ljubljana, University Medical Centre Ljubljana
- Journal
- Psychiatria Danubina
- Band
- 30
- Seiten
- 136-141
- Anzahl der Seiten
- 6
- ISSN
- 0353-5053
- DOI
- https://doi.org/10.24869/spsih.2018.136
- Publikationsdatum
- 01-2018
- Peer-reviewed
- Ja
- ÖFOS 2012
- 304002 Genetische Diagnostik
- Schlagwörter
- ASJC Scopus Sachgebiete
- Psychiatry and Mental health
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucris.univie.ac.at/portal/de/publications/the-role-of-microbiota-in-depression--a-brief-review(80d060ca-5236-46e6-86ef-330bc16b9c70).html