Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review

Autor(en)

Ermira Krasniqi, Arben Boshnjaku, Karl-Heinz Wagner, Barbara Wessner

Abstrakt

An association between vitamin D level and muscle-related traits has been frequently reported. Vitamin D level is dependent on various factors such as sunlight exposure and nutrition. But also on genetic factors. We, therefore, hypothesize that single nucleotide polymorphisms (SNPs) within the vitamin D pathway-related genes could contribute to muscle mass and function via an impact on vitamin D level. However, the integration of studies investigating these issues is still missing. Therefore, this review aimed to systematically identify and summarize the available evidence on the association between SNPs within vitamin D pathway-related genes and vitamin D status as well as various muscle traits in healthy adults. The review has been registered on PROSPERO and was conducted following PRISMA guidelines. In total, 77 studies investigating 497 SNPs in 13 different genes were included, with significant associations being reported for 59 different SNPs. Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies. Various muscle traits have been investigated only in relation to four different vitamin D receptor (VDR) polymorphisms (rs7975232, rs2228570, rs1544410, and rs731236). Interestingly, all of them showed only very low confirmation rates (6–17% of the studies). In conclusion, this systematic review presents one of the most comprehensive updates of the association of SNPs in vitamin D pathway-related genes with vitamin D status and muscle traits in healthy adults. It might be used for selecting candidate SNPs for further studies, but also for personalized strategies in identifying individuals at risk for vitamin D deficiency and eventually for determining a potential response to vitamin D supplementation.

Organisation(en)

Institut für Sport- und Bewegungswissenschaft, Forschungsplattform Active Ageing, Department für Ernährungswissenschaften

Externe Organisation(en)

University of Gjakova “Fehmi Agani”

Journal

Nutrients

Band

13

Anzahl der Seiten

24

ISSN

2072-6643

DOI

https://doi.org/10.3390/nu13093109

Publikationsdatum

09-2021

Peer-reviewed

Ja

ÖFOS 2012

303028 Sportwissenschaft, 106023 Molekularbiologie, 303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Food Science, Nutrition and Dietetics

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/association-between-polymorphisms-in-vitamin-d-pathwayrelated-genes-vitamin-d-status-muscle-mass-and-function-a-systematic-review(85600663-95a6-451d-8a5b-edb886f21cc4).html