Markers of Intestinal Permeability Are Rapidly Improved by Alcohol Withdrawal in Patients with Alcohol-Related Liver Disease

Autor(en)

Finn Jung, Katharina Burger, Raphaela Staltner, Annette Brandt, Sebastian Müller, Ina Bergheim

Abstrakt

Changes in intestinal microbiome and barrier function are critical in the development of alcohol-related liver disease (ALD). Here, we determined the effects of a one-week alcohol withdrawal on parameters of intestinal barrier function in heavy drinkers with ALD in comparison to healthy non-drinkers (controls). In serum samples of 17 controls (m = 10/f = 7) and 37 age-matched ALD patients (m = 26/f = 11) undergoing a one-week alcohol withdrawal, markers of liver health and intestinal barrier function were assessed. Liver damage, e.g., fibrosis and hepatic steatosis, were assessed using FibroScan. Before alcohol withdrawal, markers of liver damage, lipopolysaccharide binding protein (LBP) and overall TLR4/TLR2 ligands in serum were significantly higher in ALD patients than in controls, whereas intestinal fatty acid binding protein (I-FABP) and zonulin protein concentrations in serum were lower. All parameters, with the exception of LBP, were significantly improved after alcohol withdrawal; however, not to the level of controls. Our data suggest that one-week of abstinence improves markers of intestinal barrier function and liver health in ALD patients.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Universität Heidelberg

Journal

Nutrients

Band

13

Anzahl der Seiten

8

ISSN

2072-6643

DOI

https://doi.org/10.3390/nu13051659

Publikationsdatum

05-2021

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Food Science, Nutrition and Dietetics

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/markers-of-intestinal-permeability-are-rapidly-improved-by-alcohol-withdrawal-in-patients-with-alcoholrelated-liver-disease(cfea90c9-d8de-48dd-88a1-ae104b233923).html