Mediterranean dietary pattern, inflammation and endothelial function

Autor(en)

L. Schwingshackl, Georg Hoffmann

Abstrakt

Background: High adherence to a Mediterranean diet (MD) is associated with reduced all-cause and cardiovascular mortality risk. To our knowledge, there is no systematic review and meta-analysis of randomized controlled trials that has compared the effects of an MD on outcomes of endothelial function and inflammation.

 

Methods and results: Literature search was performed using the electronic databases MEDLINE, EMBASE, and the Cochrane Trial Register. Inclusion criteria were: randomized controlled trials, 19 + years of age, and minimum intervention period of 12 weeks. Study specific weighted mean differences (WMD) were pooled using a random effect model. Seventeen trials including 2300 subjects met the objectives. MD regimens resulted in a significantly more pronounced increase in flow mediated dilatation [WMD: 1.86%, 95% CI 0.23 to 3.48, p = 0.02; I-2 = 43%], and adiponectin [WMD: 1.69 mu g/ml, 95% CI 0.27 to 3.11, p = 0.02; I-2 = 78%], while high-sensitive C reactive protein [WMD: -0.98 mg/l, 95% CI -1.48 to -0.49, p <0.0001; I-2 = 91%], interleukin-6 [WMD: -0.42 pg/ml, 95% CI -0.73 to -0.11, p = 0.008; I-2 = 81%], and intracellular adhesion molecule-1 [WMD: -23.73 ng/ml, 95% CI -41.24 to -6.22 p = 0.008; I-2 = 34%] turned out to be significantly more decreased.

 

Conclusion: The results of the present meta-analysis provide evidence that an MD decreases inflammation and improves endothelial function. (C) 2014 Elsevier B. V. All rights reserved.

 

Organisation(en)

Department für Ernährungswissenschaften

Journal

Nutrition, Metabolism & Cardiovascular Diseases

Band

24

Seiten

929-939

Anzahl der Seiten

11

ISSN

0939-4753

DOI

https://doi.org/10.1016/j.numecd.2014.03.003

Publikationsdatum

09-2014

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Cardiology and Cardiovascular Medicine, Nutrition and Dietetics, Medicine (miscellaneous), Endocrinology, Diabetes and Metabolism

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/mediterranean-dietary-pattern-inflammation-and-endothelial-function(5340fae7-a3fb-4601-bfc4-46bfd9c24945).html