Effects of long term oral β-carotene supplementation on lipid peroxidation in patients with cystic fibrosis
- Autor(en)
- P. Rust, I. Eichler, S. Renner, I. Elmadfa
- Abstrakt
The aim of this study was to determine the efficacy of oral β-carotene supplementation for the correction of an oxidant-antioxidant imbalance in cystic fibrosis (CF). We studied 24 patients with cystic fibrosis and 14 healthy controls. 13 CF-patients were allocated to a CF- supplementation group, which received 1 mg β-carotene/kg BW/d up to a body weight (BW) of 50 kg, patients with a BW greater 50 kg received 50 mg β-carotene/d for 12 weeks. For the following 12 weeks all patients of the CF-supplementation group were treated with 10 mg β-carotene/d. Placebos with starch were applied to 11 CF-patients. Baseline plasma β-carotene concentrations of CF patients (mean ± SD, 0.08 ± 0.04 μmol/l) were significantly lower than those of age-matched controls (0.3 ± 0.1 μmol/l) (p < 0.001). β-carotene concentrations of the CF-supplementation group increased rapidly and reached a value of 0.6 μmol/l after 12 weeks of supplementation. Normal values were measured for plasma ascorbate and α-tocopherol. Plasma retinol concentrations were in the lower normal range and did not increase during supplementation. Total antioxidative capacity in plasma of the CF-supplementation group increased after 12 weeks of supplementation at an extent of 12%. Positive influence was indicated by a decrease of plasma malondialdehyde. Thus oral β-carotene supplementation is effective in normalizing status of β-carotene and malondialdehyde in CF patients.
- Organisation(en)
- Department für Ernährungswissenschaften
- Externe Organisation(en)
- Medizinische Universität Wien
- Journal
- International Journal for Vitamin and Nutrition Research
- Band
- 68
- Seiten
- 83-87
- Anzahl der Seiten
- 5
- ISSN
- 0300-9831
- Publikationsdatum
- 04-1998
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303009 Ernährungswissenschaften
- Schlagwörter
- ASJC Scopus Sachgebiete
- Medicine (miscellaneous), Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucris.univie.ac.at/portal/de/publications/effects-of-long-term-oral-carotene-supplementation-on-lipid-peroxidation-in-patients-with-cystic-fibrosis(6f45e443-2504-4657-9e36-502d54867c8f).html