Comparison of the long-term effects of high-fat v. low-fat diet consumption on cardiometabolic risk factors in subjects with abnormal glucose metabolism
- Autor(en)
- Lukas Schwingshackl, Georg Hoffmann
- Abstrakt
The aim of the present systematic review and meta-analysis was to examine the long-term effects ( ≥ 12 months) of high-fat (HF) v. low-fat (LF) diet consumption on the indicators of glycaemic control as well as cardiovascular risk factors in pre-diabetic and diabetic individuals. Literature search was carried out using the electronic databases MEDLINE, Embase and the Cochrane Trial Register until November 2013. Study-specific weighted mean differences (MD) were pooled using a random-effects model of the Cochrane software package Review Manager 5.1 and Stata 12.0 was used for meta-regressions. A total of fourteen trials met the inclusion criteria and a maximum of 1753 subjects were included in the meta-analysis. HF regimens were found to result in a significant decrease in TAG levels (MD - 0·19 mmol/l, 95 % CI - 0·23, - 0·14, P< 0·001; I
2= 0 %, P= 0·58) and diastolic blood pressure (MD - 1·30 mmHg, 95 % CI - 1·73, - 0·87, P< 0·001; I
2= 0 %, P= 0·60) and a significant increase in HDL-cholesterol levels (MD 0·05 mmol/l, 95 % CI 0·01, 0·08, P= 0·01; I
2= 57 %, P= 0·01). In addition, MD in the reductions of fasting glucose levels ( - 0·41 mmol/l, 95 % CI - 0·74, - 0·08, P= 0·01; I
2= 56 %, P= 0·02) were significantly high in patients with type 2 diabetes adhering to a HF diet. HF and LF diets might not be of equal value in the management of either pre-diabetes or type 2 diabetes, leading to emphasis being placed on the recommendations of HF diets.
- Organisation(en)
- Department für Ernährungswissenschaften
- Journal
- British Journal of Nutrition
- Band
- 111
- Seiten
- 2047-2058
- Anzahl der Seiten
- 12
- ISSN
- 0007-1145
- DOI
- https://doi.org/10.1017/S0007114514000464
- Publikationsdatum
- 06-2014
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303009 Ernährungswissenschaften
- Schlagwörter
- ASJC Scopus Sachgebiete
- Nutrition and Dietetics, Medicine (miscellaneous)
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/comparison-of-the-longterm-effects-of-highfat-v-lowfat-diet-consumption-on-cardiometabolic-risk-factors-in-subjects-with-abnormal-glucose-metabolism(080f2f3f-8ef2-4c9d-9a8b-34bdbe0eb455).html