The relevance of intestinal barrier dysfunction, antimicrobial proteins and bacterial endotoxin in metabolic dysfunction-associated steatotic liver disease

Autor(en)

Ina Bergheim, José María Moreno-Navarrete

Abstrakt

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of end-stage liver disease associated with increased mortality and cardiovascular disease. Obesity and diabetes are the most important risk factors of MASLD. It is well-established that obesity-associated insulin resistance leads to a situation of tissue lipotoxicity characterized by an accumulation of excess fat in non-fat tissues such as the liver, promoting the development of MASLD, and its progression into metabolic dysfunction-associated steatohepatitis. Methods: Here, we aimed to review the impact of disrupted intestinal permeability, antimicrobial proteins and bacterial endotoxin in the development and progression of MASLD. Results and Conclusion: Recent studies demonstrated that obesity- and obesogenic diets-associated alterations of intestinal microbiota along with the disruption of intestinal barrier integrity, the alteration in antimicrobial proteins and, in consequence, an enhanced translocation of bacterial endotoxin into bloodstream might contribute to this pathological process through to impacting liver metabolism and inflammation.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Instituto de Investigación Biomédica de Girona Josep Trueta, Instituto de Salud Carlos III (ISCIII), Universitat de Girona

Journal

European Journal of Clinical Investigation

Band

54

ISSN

0014-2972

DOI

https://doi.org/10.1111/eci.14224

Publikationsdatum

07-2024

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Biochemistry, Clinical Biochemistry

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/a163da4e-8a3e-4358-b818-dc74aa17ece3