Hohenheimer konsensusgesprach kupfer

Autor(en)

K. Schümann, H. G. Classen, H. H. Dieter, J. König, G. Multhaup, M. Rükgauer, K. H. Summer, J. Bernhardt, H. K. Biesalski

Abstrakt

Copper (Cu) is an essential trace element with many physiological functions. Homeostatic mechanisms exist to allow Cu to act as a cofactor in enzymatic processes and to prevent accumulation of Cu to toxic levels. The aim of this commentary is to better understand the role of dietary Cu supply in deficiency under physiological and pathological conditions. The essentiality of Cu can be attributed to its role as a cofactor in a number of enzymes that are involved in the defence of oxidative stress. Cu, however, has a second face, that of a toxic compound as it is observed with accumulating evidence in neurodegenerative and cardiovascular diseases. The destructive potential of Cu can be attributed to inherent properties. The main is its ability to take part in Fenton-like reactions in which the highly reactive and extremely deleterious hydroxyl radical is formed. Most likely, dietary Cu overload is based on a genetic predisposition. Thus, an assessment of risk-groups, such as infants with impaired mechanisms of Cu homeostasis regarding detoxification, is of special interest, as their Cu intake with resuspended formula milk may be considerably too high. This implies the need for reliable diagnostic markers to determine the Cu status. These topics were introduced at the workshop by all participants followed by extensive group discussion. The consensus statement was agreed on by all members. One of the conclusions is that a re-assessment of published data is necessary and future research is required.

Organisation(en)

Externe Organisation(en)

Universität Hohenheim

Journal

Aktuelle Ernahrungsmedizin

Band

24

Seiten

283-296

Anzahl der Seiten

14

ISSN

0341-0501

Publikationsdatum

12-1999

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

ASJC Scopus Sachgebiete

Medicine (miscellaneous), Nutrition and Dietetics

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/hohenheimer-konsensusgesprach-kupfer(869a3b05-fa8f-40dc-ba7c-417a3280ad6e).html