Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease

Autor(en)

Reinhard Gruendler, Berit Hippe, Vesna Sendula Jengic, Borut Peterlin, Alexander G. Haslberger

Abstrakt

Aging and the emergence of age-associated illnesses are one of the major challenges of our present society. Alzheimer's disease (AD) is closely associated with aging and is defined by increasing memory loss and severe dementia. Currently, there are no therapy options available that halt AD progression. This work investigates three hallmarks of the disease (autophagy, neuroinflammation, and senescence) and systematically analyzes if there is a beneficial effect from three substances derived from food sources, the so called "nutraceuticals" epigallocatechin gallate, fisetin, and spermidine, on these hallmarks. The results imply a positive outlook for the reviewed substances to qualify as a novel treatment option for AD. A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Psychiatric hospital Rab, HealthBioCare GmbH, Universität Wien

Journal

Molecules

Band

25

Anzahl der Seiten

21

ISSN

1420-3049

DOI

https://doi.org/10.3390/molecules25246018

Publikationsdatum

12-2020

Peer-reviewed

Ja

ÖFOS 2012

301209 Pharmazie

Schlagwörter

ASJC Scopus Sachgebiete

Drug Discovery, Analytical Chemistry, Chemistry (miscellaneous), Molecular Medicine, Physical and Theoretical Chemistry, Pharmaceutical Science, Organic Chemistry

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/nutraceutical-approaches-of-autophagy-and-neuroinflammation-in-alzheimers-disease(609cfac4-d428-4a4a-96c4-da74bed11e3f).html