Microbiota and epigenetic regulation of inflammatory mediators
- Autor(en)
- Marlene Remely, Heidrun Karlic, Irene Rebhan, Martina Greunz, Alexander G. Haslberger
- Abstrakt
Bacteria and bacterial derived metabolites are known to influence the host epigenetic regulation patterns such as DNA methylation and histone modifications, thus altering the expression of critical genes in pathologic processes, for example in metabolic syndrome. Fermentation end products, especially butyrate and LPS (lipopolysaccharides), the latter being cell-wall components of gram-negative bacteria, have been suggested as bioactive metabolites influencing epigenetic modifications by directly influencing enzymes catalyzing epigenetic modifications, by altering the availability of substrates, or by interactions with receptors. Thus, identification and quantification of gut microbiota via molecular based methods are of importance to address different epigenetic patterns and gene expression. We discuss methods for microbiota, epigenetic methylation, and expression analysis of our own research which will have a role in future studies.
- Organisation(en)
- Department für Ernährungswissenschaften
- Externe Organisation(en)
- Hanusch Krankenhaus
- Seiten
- 115-134
- Anzahl der Seiten
- 20
- DOI
- https://doi.org/10.1007/978-1-4939-6743-8_8
- Publikationsdatum
- 2017
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303020 Medizinische Mikrobiologie
- Schlagwörter
- ASJC Scopus Sachgebiete
- Molecular Medicine, Pharmacology, Toxicology and Pharmaceutics(all), Pharmacology (medical)
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/6ed8a4a1-385d-47e1-bcc5-3bbde371d51d