Effects of long term oral β-carotene supplementation on lipid peroxidation in patients with cystic fibrosis

Autor(en)

P. Rust, I. Eichler, S. Renner, I. Elmadfa

Abstrakt

The aim of this study was to determine the efficacy of oral β-carotene supplementation for the correction of an oxidant-antioxidant imbalance in cystic fibrosis (CF). We studied 24 patients with cystic fibrosis and 14 healthy controls. 13 CF-patients were allocated to a CF- supplementation group, which received 1 mg β-carotene/kg BW/d up to a body weight (BW) of 50 kg, patients with a BW greater 50 kg received 50 mg β-carotene/d for 12 weeks. For the following 12 weeks all patients of the CF-supplementation group were treated with 10 mg β-carotene/d. Placebos with starch were applied to 11 CF-patients. Baseline plasma β-carotene concentrations of CF patients (mean ± SD, 0.08 ± 0.04 μmol/l) were significantly lower than those of age-matched controls (0.3 ± 0.1 μmol/l) (p < 0.001). β-carotene concentrations of the CF-supplementation group increased rapidly and reached a value of 0.6 μmol/l after 12 weeks of supplementation. Normal values were measured for plasma ascorbate and α-tocopherol. Plasma retinol concentrations were in the lower normal range and did not increase during supplementation. Total antioxidative capacity in plasma of the CF-supplementation group increased after 12 weeks of supplementation at an extent of 12%. Positive influence was indicated by a decrease of plasma malondialdehyde. Thus oral β-carotene supplementation is effective in normalizing status of β-carotene and malondialdehyde in CF patients.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Medizinische Universität Wien

Journal

International Journal for Vitamin and Nutrition Research

Band

68

Seiten

83-87

Anzahl der Seiten

5

ISSN

0300-9831

Publikationsdatum

04-1998

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Medicine (miscellaneous), Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/6f45e443-2504-4657-9e36-502d54867c8f