Long-term oral β-carotene supplementation in patients with cystic fibrosis - Effects on antioxidative status and pulmonary function

Autor(en)

Petra Rust, Irmgard Eichler, Sabine Renner, Ibrahim Elmadfa

Abstrakt

To investigate the efficacy of long-term oral β-carotene supplementation for optimizing the antioxidant status and pulmonary function in patients with cystic fibrosis (CF), 24 patients (aged 12.8 ± 6.3 years) were randomized to a CF supplementation or to a CF placebo group. As controls 14 healthy age-matched subjects (aged 14.7 ± 6.2 years) were studied. Patients of the CF supplementation group received 1 mg β-carotene/kg body weight (BW)/day (maximally 50 mg β-carotene/day) for the first 12 weeks; during the following 12 weeks, dosage was reduced to 10 mg β-carotene/day. At study entry, plasma β-carotene concentrations were significantly lower in CF patients than in controls (p < 0.001). In the CF supplementation group, plasma β-carotene concentrations were significantly increased (baseline: 0.08 ± 0.04 μmol/l) at the end of high-dose treatment (12th week; 0.6 ± 0.4 μmol/l; p < 0.001), but decreased again during supplementation with 10 mg β-carotene/day to 0.3 ± 0.2 μmol/l at the end of the study (p < 0.001). β-Carotene supplementation did not affect plasma concentrations of other carotenoids and retinol, but an increase in plasma α- and γ-tocopherol concentrations was noticed. During high-dose treatment, a significant decrease in TBA-MDA complexes and a correction of total antioxidative capacity was observed. During the treatment, pulmonary exacerbation could be corrected significantly (p < 0.05). We conclude that CF patients can be efficiently supplemented with 1 mg β-carotene/kg BW/day (maximally 50 mg β-carotene/day) to achieve plasma concentrations of healthy control subjects and to minimize oxidative stress, improving the quality of life of CF patients. Copyright (C) 2000 S. Karger AG, Basel.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Allgemeines Krankenhaus der Stadt Wien (AKH)

Journal

Annals of Nutrition and Metabolism: European journal of nutrition, metabolic diseases and dietetics

Band

44

Seiten

30-37

Anzahl der Seiten

8

ISSN

0250-6807

DOI

https://doi.org/10.1159/000012818

Publikationsdatum

01-2000

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Medicine (miscellaneous), Nutrition and Dietetics

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/c9778d90-1bb1-444a-831c-7583b4951a46