Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis

Autor(en)
Cathrin Sellmann, Christian Degen, Cheng Jun Jin, Anika Nier, Anna Janina Engstler, Dana Hasan Alkhatib, Jean Pascal De Bandt, Ina Bergheim
Abstrakt

Dietary arginine (Arg) supplementation has been proposed to have positive effects on the development of liver diseases. In the present study, we investigate if an oral Arg supplementation in diet protects mice fed a fructose, fat and cholesterol enriched Western-style diet (WSD) from the development of non-alcoholic steatohepatitis (NASH). Female C57BL/6J mice were fed a liquid control diet or a liquid WSD ± Arg (2.49 g/kg body weight/day) for 6 weeks. Indices of liver injury, glucose metabolism and intestinal permeability were determined. While Arg supplementation had no effects on body weight gain, fasting blood glucose levels were significantly lower in WSD+Arg-fed mice than in C+Arg-fed animals. WSD-fed mice developed liver steatosis accompanied with inflammation, both being significantly attenuated in WSD+Arg-fed mice. These effects of Arg supplementation went along with a protection against WSD-induced decreased tight junction protein levels in the upper parts of the small intestine, increased levels of bacterial endotoxin in portal plasma as well as increased hepatic toll-like receptor-4 mRNA and 4-hydroxynonenal protein adduct levels. In conclusion, Arg supplementation may protect mice from the development of NASH.

Organisation(en)
Department für Ernährungswissenschaften
Externe Organisation(en)
United Arab Emirates University, Friedrich-Schiller-Universität Jena, EA4466, Sorbonne Paris Cité, and Clinical Chemistry Department, Hôpitaux Universitaires Paris Centre, APHP, Paris, France.
Journal
Amino Acids
Band
49
Seiten
1215-1225
Anzahl der Seiten
11
ISSN
0939-4451
DOI
https://doi.org/10.1007/s00726-017-2423-4
Publikationsdatum
07-2017
Peer-reviewed
Ja
ÖFOS 2012
303009 Ernährungswissenschaften
Schlagwörter
ASJC Scopus Sachgebiete
Biochemistry, Clinical Biochemistry, Organic Chemistry
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/oral-arginine-supplementation-protects-female-mice-from-the-onset-of-nonalcoholic-steatohepatitis(0b4aa749-273f-472b-8c65-f4400a0c4c4e).html