Fortifying diet with rapeseed oil instead of butterfat attenuates the progression of diet-induced non-alcoholic fatty liver disease (NAFLD) and impairment of glucose tolerance
- Autor(en)
- Annette Brandt, Dragana Rajcic, Cheng Jun Jin, Victor Manuel Sanchez Juarez, Anna Engstler, Finn Jung, Anika Nier, Anja Baumann, Ina Bergheim
- Abstrakt
Background: Absolute dietary fat intake but even more so fatty acid pattern is discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). Here, we determined if switching a butterfat enriched diet to a rapeseed oil (RO) enriched diet affects progression of an existing NAFLD and glucose intolerance in mice. Methods: For eight weeks, female C57Bl/6J mice were either fed a liquid control (C) or a butterfat-, fructose- and cholesterol-rich diet (BFC, 25E% butterfat) to induce early signs of steatohepatitis and glucose intolerance in mice. For additional five weeks mice received either BFC or C or a fat-, fructose- and cholesterol-rich and control diet, in which butterfat was replaced with RO (ROFC and CRO). Markers of glucose metabolism, liver damage and intestinal barrier were assessed. Results: Exchanging butterfat with RO attenuated the progression of BFC diet-induced NAFLD and glucose intolerance. Beneficial effects of RO were associated with lower portal endotoxin levels and an attenuation of the induction of the toll-like receptor-4-dependent signaling cascades in liver. Peroxisome proliferator-activated receptor γ activity was induced in small intestine of ROFC-fed mice. Conclusion: Taken together, exchanging butterfat with RO attenuated the progression of diet-induced steatohepatitis and glucose intolerance in mice.
- Organisation(en)
- Department für Ernährungswissenschaften
- Externe Organisation(en)
- Friedrich-Schiller-Universität Jena
- Journal
- Metabolism
- Band
- 109
- Anzahl der Seiten
- 10
- ISSN
- 0026-0495
- DOI
- https://doi.org/10.1016/j.metabol.2020.154283
- Publikationsdatum
- 06-2020
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303009 Ernährungswissenschaften
- Schlagwörter
- ASJC Scopus Sachgebiete
- Endocrinology, Endocrinology, Diabetes and Metabolism
- Link zum Portal
- https://ucris.univie.ac.at/portal/de/publications/fortifying-diet-with-rapeseed-oil-instead-of-butterfat-attenuates-the-progression-of-dietinduced-nonalcoholic-fatty-liver-disease-nafld-and-impairment-of-glucose-tolerance(306afbda-f40e-4074-82bd-226be8a0016f).html