Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine.

Autor(en)

Annette Brandt, Angélica Hernández-Arriaga, Richard Kehm, Victor Manuel Sanchez Juarez, Cheng Jun Jin, Anika Nier, Anja Baumann, Amélia Camarinha Silva, Ina Bergheim

Abstrakt

The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease (NAFLD) through its effects on intestinal microbiota and barrier function. However, so far most studies focused on long-term effects and more progressed disease stages. The aim of this study was to assess in two experimental settings, if the onset of NAFLD is associated with changes of intestinal microbiota and barrier function and to determine effects of metformin herein. C57BL/6J mice were fed a liquid control diet (C) or fat-, fructose- and cholesterol-rich diet (FFC) for four days or six weeks +/- 300 mg/kg BW/day metformin (Met). Markers of liver health, intestinal barrier function and microbiota composition were assessed. Metformin treatment markedly attenuated FFC-induced NAFLD in both experiments with markers of inflammation and lipidperoxidation in livers of FFC + Met-fed mice being almost at the level of controls. Metformin treatment attenuated the loss of tight junction proteins in small intestine and the increase of bacterial endotoxin levels in portal plasma. Changes of intestinal microbiota found in FFC-fed mice were also significantly blunted in FFC + Met-fed mice. Taken together, protective effects of metformin on the onset of NAFLD are associated with changes of intestinal microbiota composition and lower translocation of bacterial endotoxins.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Universität Hohenheim, Universität Potsdam, Friedrich-Schiller-Universität Jena

Journal

Scientific Reports

Band

9

Anzahl der Seiten

14

ISSN

2045-2322

DOI

https://doi.org/10.1038/s41598-019-43228-0

Publikationsdatum

04-2019

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/metformin-attenuates-the-onset-of-nonalcoholic-fatty-liver-disease-and-affects-intestinal-microbiota-and-barrier-in-small-intestine(67aa9119-650c-4796-bd3a-65f334ca1390).html