Fortifying diet with rapeseed oil instead of butterfat attenuates the progression of diet-induced non-alcoholic fatty liver disease (NAFLD) and impairment of glucose tolerance

Autor(en): Annette Brandt, Dragana Rajcic, Cheng Jun Jin, Victor Manuel Sanchez Juarez, Anna Engstler, Finn Jung, Anika Nier, Anja Baumann, Ina Bergheim
Abstrakt: Background: Absolute dietary fat intake but even more so fatty acid pattern is discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). Here, we determined if switching a butterfat enriched diet to a rapeseed oil (RO) enriched diet affects progression of an existing NAFLD and glucose intolerance in mice. Methods: For eight weeks, female C57Bl/6J mice were either fed a liquid control (C) or a butterfat-, fructose- and cholesterol-rich diet (BFC, 25E% butterfat) to induce early signs of steatohepatitis and glucose intolerance in mice. For additional five weeks mice received either BFC or C or a fat-, fructose- and cholesterol-rich and control diet, in which butterfat was replaced with RO (ROFC and CRO). Markers of glucose metabolism, liver damage and intestinal barrier were assessed. Results: Exchanging butterfat with RO attenuated the progression of BFC diet-induced NAFLD and glucose intolerance. Beneficial effects of RO were associated with lower portal endotoxin levels and an attenuation of the induction of the toll-like receptor-4-dependent signaling cascades in liver. Peroxisome proliferator-activated receptor γ activity was induced in small intestine of ROFC-fed mice. Conclusion: Taken together, exchanging butterfat with RO attenuated the progression of diet-induced steatohepatitis and glucose intolerance in mice.
Organisation(en): Department für Ernährungswissenschaften
Externe Organisation(en): Friedrich-Schiller-Universität Jena
Journal: Metabolism
Band: 109
Anzahl der Seiten: 10
ISSN: 0026-0495
DOI: https://doi.org/10.1016/j.metabol.2020.154283
Publikationsdatum: 06-2020
Peer-reviewed: Ja
ÖFOS 2012: 303009 Ernährungswissenschaften
Schlagwörter
ASJC Scopus Sachgebiete: Endocrinology, Endocrinology, Diabetes and Metabolism
Link zum Portal: https://ucrisportal.univie.ac.at/de/publications/306afbda-f40e-4074-82bd-226be8a0016f