Hops (Humulus lupulus) Content in Beer Modulates Effects of Beer on the Liver After Acute Ingestion in Female Mice

Autor(en)
Marianne Landmann, Cathrin Sellmann, Anna Janina Engstler, Doreen Ziegenhardt, Finn Jung, Christine Brombach, Ina Bergheim
Abstrakt

AIM: Using a binge-drinking mouse model, we aimed to determine whether hops (Humulus lupulus) in beer is involved in the less damaging effects of acute beer consumption on the liver in comparison with ethanol.

METHODS: Female C57BL/6 J mice were either fed one iso-alcoholic and iso-caloric bolus dose of ethanol, beer, beer without hops (6 g ethanol/kg body weight) or an iso-caloric bolus of maltodextrin control solution. Markers of steatosis, intestinal barrier function, activation of toll-like receptor 4 signaling cascades, lipid peroxidation and lipogenesis were determined in liver, small intestine and plasma 2 h and 12 h after acute alcohol ingestion.

RESULTS: Alcohol-induced hepatic fat accumulation was significantly attenuated in mice fed beer whereas in those fed beer without hops, hepatic fat accumulation was similar to that found in ethanol-fed mice. While markers of intestinal barrier function e.g. portal endotoxin levels and lipogenesis only differed slightly between groups, hepatic concentrations of myeloid differentiation primary response gene 88, inducible nitric oxide synthase (iNOS) and plasminogen-activator inhibitor 1 protein as well as of 4-hydroxynonenal and 3-nitrotyrosine protein adducts were similarly elevated in livers of mice fed ethanol or beer without hops when compared with controls. Induction of these markers was markedly attenuated in mice fed hops-containing beer.

CONCLUSION: Taken together, our data suggest that hops in beer markedly attenuated acute alcohol-induced liver steatosis in female mice through mechanisms involving a suppression of iNOS induction in the liver.

Organisation(en)
Externe Organisation(en)
Friedrich-Schiller-Universität Jena
Journal
Alcohol & Alcoholism
Band
52
Seiten
48-55
Anzahl der Seiten
8
DOI
https://doi.org/10.1093/alcalc/agw060
Publikationsdatum
01-2017
Peer-reviewed
Ja
ÖFOS 2012
303009 Ernährungswissenschaften
ASJC Scopus Sachgebiete
Medicine (miscellaneous), Medicine(all), Toxicology, Psychiatry and Mental health
Sustainable Development Goals
SDG 3 – Gesundheit und Wohlergehen
Link zum Portal
https://ucrisportal.univie.ac.at/de/publications/hops-humulus-lupulus-content-in-beer-modulates-effects-of-beer-on-the-liver-after-acute-ingestion-in-female-mice(aaa736b8-8986-443e-ad61-ecd2d4cb99a7).html