TNFα is a key trigger of inflammation in diet-induced non-obese MASLD in mice

Autor(en)

Katharina Burger, Finn Jung, Anja Baumann, Annette Brandt, Raphaela Staltner, Victor Manuel Sanchez Juarez, Ina Bergheim

Abstrakt

Tumor necrosis factor alpha (TNFα) is thought to be a critical factor in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we determined the effects of a treatment with the anti-TNFα antibody infliximab and a genetic deletion of TNFα, respectively, in the development of non-obese diet-induced early metabolic dysfunction-associated steatohepatitis (MASH) in mice. The treatment with infliximab improved markers of liver damage in mice with pre-existing early MASH. In TNFα

^−/− mice, the development of early signs of MASH and insulin resistance was significantly attenuated compared to wild-type animals. While mRNA expression of proinflammatory cytokines like interleukin 1β (Il1b) and interleukin 6 (Il6) were significantly lower in livers of MASH-diet-fed TNFα

^−/− mice compared to wild-type mice with early MASH, markers of intestinal barrier function were similarly impaired in both MASH-diet-fed groups compared to controls. Our data suggest that TNFα is a key regulator of hepatic inflammation and insulin resistance associated with the development of early non-obese MASH.

Organisation(en)

Department für Ernährungswissenschaften

Journal

Redox biology

Band

ISSN

2213-2317

Publikationsdatum

10-2023

Peer-reviewed

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Organic Chemistry

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/tnf-is-a-key-trigger-of-inflammation-in-dietinduced-nonobese-masld-in-mice(b1fcc153-8357-4e57-b2f1-4eefd558d117).html