The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease

Autor(en)

Xu-Fen Zeng, Krista A Varady, Xiang-Dong Wang, Giovanni Targher, Christopher D Byrne, Reema Tayyem, Giovanni Latella, Ina Bergheim, Rodrigo Valenzuela, Jacob George, Carolyn Newberry, Ju-Sheng Zheng, Elena S George, C Wendy Spearman, Meropi D Kontogianni, Danijela Ristic-Medic, Wilza Arantes Ferreira Peres, Gamze Yurtdaş Depboylu, Wanshui Yang, Xu Chen, Fredrik Rosqvist, Christos S Mantzoros, Luca Valenti, Hannele Yki-Järvinen, Antonella Mosca, Silvia Sookoian, Anoop Misra, Yusuf Yilmaz, Won Kim, Yasser Fouad, Giada Sebastiani, Vincent Wai-Sun Wong, Fredrik Åberg, Yu Jun Wong, Pianhong Zhang, Francisco-Javier Bermúdez-Silva, Yan Ni, Monica Lupsor-Platon, Wah Kheong Chan, Nahum Méndez-Sánchez, Robert J de Knegt, Shahinul Alam, Sombat Treeprasertsuk, Li Wang, Mulong Du, Tiejun Zhang, Ming-Lung Yu, Huijie Zhang, Xingshun Qi, Xin Liu, Kanokwan Pinyopornpanish, Yu-Chen Fan, Kaijun Niu, Josep C Jimenez-Chillaron, Ming-Hua Zheng

Abstrakt

Metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), has become the leading cause of chronic liver disease worldwide. Optimal dietary intervention strategies for MAFLD are not standardized. This study aimed to achieve consensus on prevention of MAFLD through dietary modification. A multidisciplinary panel of 55 international experts, including specialists in hepatology, gastroenterology, dietetics, endocrinology and other medical specialties from six continents collaborated in a Delphi-based consensus development process. The consensus statements covered aspects ranging from epidemiology to mechanisms, management, and dietary recommendations for MAFLD. The recommended dietary strategies emphasize adherence to a balanced diet with controlled energy intake and personalized nutritional interventions, such as calorie restriction, high-protein, or low-carbohydrate diets. Specific dietary advice encouraged increasing the consumption of whole grains, plant-based proteins, fish, seafood, low-fat or fat-free dairy products, liquid plant oils, and deeply colored fruits and vegetables. Concurrently, it advised reducing the intake of red and processed meats, saturated and trans fats, ultra-processed foods, added sugars, and alcohol. Additionally, maintaining the Mediterranean or DASH diet, minimizing sedentary behavior, and engaging in regular physical activity are recommended. These consensus statements lay the foundation for customized dietary guidelines and proposing avenues for further research on nutrition and MAFLD.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

The First Affiliated Hospital of Wenzhou Medical University, University of Illinois at Chicago, Tufts University, Boston, MA, Università degli Studi di Verona, IRCCS Sacro Cuore-Don Calabria Hospital, University of Southampton, University Hospital Southampton, Qatar University, Università degli Studi dell’Aquila, Universidad de Chile, The University of Sydney, Westmead Hospital, Weill Cornell Medical Center, New York, Westlake University, Deakin University, University of Cape Town, Harokopio University of Athens, University of Belgrade, Universidade Federal do Estado do Rio de Janeiro, İzmir Kâtip Çelebi Üniversitesi, Anhui Medical University, Sun Yat-sen University, Uppsala University, Harvard Medical School, Boston, Università IULM, Milano, University of Helsinki, Helsinki University Hospital, Minerva Foundation Institute for Medical Research, IRCCS Bambino Gesù Children's Hospital, Maimónides University, Fortis C-DOC, Diabetes Foundation (India), Recep Tayyip Erdogan Üniversitesi, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Minya University, McGill University, Chinese University of Hong Kong, Changi General Hospital, National University of Singapore (NUS), Zhejiang University (ZJU), IBIMA Plataforma BIONAND, Universidad de Málaga, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Iuliu Hațieganu University of Medicine and Pharmacy, University of Malaya , Universidad Nacional Autonoma de Mexico, Erasmus Universitair Medisch Centrum Rotterdam, Bangabandhu Sheikh Mujib Medical University, Chulalongkorn University, Capital Medical University (CUM), Nanjing Medical University, Fudan University, Kaohsiung Medical University, National Sun Yat-sen University, Southern Medical University, General Hospital of Northern Theater Command, Shenyang, Liaoning, Xi'an Jiaotong University (XJTU), Chiang Mai University, Shandong University, Tianjin University, Tianjin Medical University, Institut de Recerca Sant Joan de Déu, Universitat de Barcelona, Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province

Journal

Metabolism

Band

161

ISSN

0026-0495

DOI

https://doi.org/10.1016/j.metabol.2024.156028

Publikationsdatum

12-2024

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Endocrinology, Endocrinology, Diabetes and Metabolism

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/bc1cd100-1882-4505-b859-aace6b0d633e