Oral supplementation of sodium butyrate attenuates the progression of non-alcoholic steatohepatitis

Autor(en)

Anja Baumann, Cheng Jun Jin, Annette Brandt, Cathrin Sellmann, Anika Nier, Markus Burkhard, Sascha Venturelli, Ina Bergheim

Abstrakt

Sodium butyrate (SoB) supplementation has been suggested to attenuate the development of non-alcoholic fatty liver disease (NAFLD). Here, we determined the therapeutic potential of SoB on NAFLD progression and molecular mechanism involved. Eight-week old C57BL/6J mice were pair-fed a fat-, fructose- and cholesterol-rich diet (FFC) or control diet (C). After 8 weeks, some mice received 0.6g SoB/kg bw in their respective diets (C+SoB; FFC+SoB) or were maintained on C or FFC for the next 5 weeks of feeding. Liver damage, markers of glucose metabolism, inflammation, intestinal barrier function and melatonin metabolism were determined. FFC-fed mice progressed from simple steatosis to early non-alcoholic steatohepatitis, along with significantly higher TNF alpha and IL-6 protein levels in the liver and impaired glucose tolerance. In FFC+SoB-fed mice, disease was limited to steatosis associated with protection against the induction of Tlr4 mRNA and iNOS protein levels in livers. SoB supplementation had no effect on FFC-induced loss of tight junction proteins in the small intestine but was associated with protection against alterations in melatonin synthesis and receptor expression in the small intestine and livers of FFC-fed animals. Our results suggest that the oral supplementation of SoB may attenuate the progression of simple steatosis to steatohepatitis.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Universitätsklinikum Tübingen, Universität Hohenheim, Friedrich-Schiller-Universität Jena

Journal

Nutrients

Band

12

Anzahl der Seiten

19

ISSN

2072-6643

DOI

https://doi.org/10.3390/nu12040951

Publikationsdatum

03-2020

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Food Science, Nutrition and Dietetics

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/oral-supplementation-of-sodium-butyrate-attenuates-the-progression-of-nonalcoholic-steatohepatitis(ed1575bb-4d4a-4098-81e3-2fbbe069d53b).html