Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia

Autor(en)

Anela Tosevska, Christine Moelzer, Marlies Wallner, Milan Janosec, Ursula Schwarz, Carina Kern, Rodrig Marculescu, Daniel Doberer, Wolfram Weckwerth, Karl-Heinz Wagner

Abstrakt

Bilirubin (BR) is a natural endogenous compound with a potent bioactivity. Gilbert's Syndrome (GS) is a benign hereditary condition of increased unconjugated bilirubin (UCB) in serum and serves as a convenient model for studying the effects of BR in humans. In absence of liver disease, increased UCB levels are inversely associated to all-cause mortality risk, especially from cardiovascular diseases (CVDs). On the other hand, telomere malfunction is linked to a higher risk of CVDs. To our knowledge, there is no data on whether UCB is linked to telomere length in healthy or diseased individuals In the present study we have observed a relationship between mildly increased serum UCB and telomere length. We used an in vivo approach, assessing telomere length in PBMCs from individuals with GS (n = 60) and matched healthy controls (n = 60). An occurrence of longer telomeres was observed in male individuals chronically exposed to increased UCB, as well as in Gunn rats, an animal model of unconjugated hyperbilirubinaemia. Previously identified differences in immunomodulation and redox parameters in individuals with GS, such as IL-6, IL-1β and ferric reducing ability of plasma, were confirmed and proposed as possible contributors to the occurrence of longer telomeres in GS.

Organisation(en)

Forschungsplattform Active Ageing, Department für Ernährungswissenschaften, Forschungsplattform Vienna Metabolomics Center

Externe Organisation(en)

Fachhochschule Joanneum, Medizinische Universität Wien

Journal

Scientific Reports

Band

6

Anzahl der Seiten

11

ISSN

2045-2322

DOI

https://doi.org/10.1038/srep22300

Publikationsdatum

03-2016

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/longer-telomeres-in-chronic-moderate-unconjugated-hyperbilirubinaemia(2322933e-87cb-4b03-894c-ff0cb25347a4).html