Association between salt intake and gastric atrophy by Helicobacter pylori infection

Viktoria Knaze, Heinz Freisling, Paz Cook, Katy Heise, Johanna Acevedo, Marcos Cikutovic, Karl-Heinz Wagner, Rodrig Marculescu, Catterina Ferreccio, Rolando Herrero, Jin Young Park

PURPOSE: Gastric atrophy (GA), usually linked to chronic infection with Helicobacter pylori (H. pylori), may over time evolve into gastric malignancy. Besides H. pylori, high salt intake may play a role in GA development. This study evaluates cross sectionally the association between salt intake and GA in Chilean adults.

METHODS: Population-based samples were recruited from two sites, Antofagasta and Valdivia, partaking in the Epidemiological Investigation of Gastric Malignancies. At recruitment, participants answered questionnaires and provided biospecimens. Salt intake (g/day) was estimated from casual spot urine samples using the Tanaka equation. GA was determined by serum pepsinogen levels. Only participants ≥ 40 to 70 years of age were considered in this analysis, n = 565. For the association between salt intake (as sex-specific quartiles) and GA, odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were estimated through multivariable logistic regression.

RESULTS: In women, the multivariable-adjusted OR for GA comparing quartile 4 of the estimated salt intake (12.8 g/day) to quartile 1 (6.6 g/day) was 1.18 (95% CI 0.52-2.68, P-trend = 0.87). The corresponding OR in men was 0.49 (95% CI 0.19-1.27, P-trend = 0.17) with salt intakes of 12.8 g/day and 7.1 g/day for quartiles 4 and 1, respectively.

CONCLUSION: There was little evidence for an association between salt intake estimated from spot urine and GA risk in our cross-sectional analysis of middle aged and older adults in Chile. Reverse causation bias cannot be ruled out and the sample size was limited to provide more precise estimates.

Department für Ernährungswissenschaften
Externe Organisation(en)
International Agency for Research on Cancer (IARC-WHO), Pontificia Universidad Católica de Chile, Advanced Center for Chronic Diseases, University of North Carolina at Chapel Hill, Hospital Base de Valdivia, Ministry of Health Chile, Universidad de Antofagasta, Medizinische Universität Wien, Fundación Inciensa
European Journal of Nutrition
Anzahl der Seiten
ÖFOS 2012
303009 Ernährungswissenschaften
ASJC Scopus Sachgebiete
Nutrition and Dietetics, Medicine (miscellaneous)
Link zum Portal