Antioxidant and cancer protective effects of gallic acid in vitro and in vivo

Autor(en)

Franziska Ferk, Armen Nersesyan, Miroslav Mišik, Karl Heinz Wagner, Siegfried Knasmüller

Abstrakt

Recent findings of our group indicate that a small amount of gallic acid (GA 12 mg/P/d) protects humans against DNA damage and induces the activities of antioxidant enzymes. Furthermore, we saw in animal studies that similar doses prevent damage of the genetic material in inner organs of rats and the induction of preneoplastic hepatic foci by γ-radiation. These promising findings stimulated us to evaluate the current knowledge on ROS and cancer protective properties of the phenolic. Approximately a dozen in vitro studies have been published which concern the antioxidant properties of GA; with high concentrations sometimes pro-oxidant effects were observed. Also a few in vivo results which were obtained with laboratory rodents are available which indicate GA induces ROS protective enzymes possibly via induction of the transcription factor Nrf2. In regard to the cancer protective properties of the compound, it is notable that in vitro experiments showed that GA inhibits cell cycle progression at G0/G1 and also at G2/M, (via modulation of the transcription of cyclines) and induces apoptosis in various human cancer cell lines (possible modes of action are inhibition of the synthesis of DNA bases, induction of NfκB, depletion of glutathione and release of ROS). Furthermore, was found that the phenolic decreases the motility and adhesion of cancer cells, inhibits metastasis and prevents angiogenesis via inhibition of VEGF. Also data from animal experiments (xenograft models with mice) show that the compound prevents the tumour growth. Most of these findings were obtained with doses which are substantially higher as the daily intake of GA via the diet which is in Middle Europe in the rage of 18 mg/P/d; however some findings were seen with lower levels that can be easily reached after increase of theconsumption by dietary measures. Taken together the current data indicate that GA is an extremely potent antioxidant in humans and may protect against malignant diseases.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Institute of Cancer Research, Medizinische Universität Wien

Seiten

265-285

Anzahl der Seiten

21

Publikationsdatum

2013

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

ASJC Scopus Sachgebiete

Biochemistry, Genetics and Molecular Biology(all)

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/antioxidant-and-cancer-protective-effects-of-gallic-acid-in-vitro-and-in-vivo(4e2dac99-4152-42d7-99cb-62a5fb089da2).html