Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men

Autor(en)

Leon J. Schurgers, Martin J. Shearer, Berry A.M. Soute, Ibrahim Elmadfa, Julia Harvey, Karl Heinz Wagner, Richard Tomasch, Cees Vermeer

Abstrakt

Little is known of how the fat components of diets influence the absorption and metabolism of vitamin K and the possible consequences to the synthesis of vitamin K-dependent (VKD) proteins in different target organs. We have evaluated the effects of two diets on circulating phylloquinone (K₁) and triacylglycerols (TAG). One diet was enriched with corn oil (CO) (also rich in γ-tocopherol) and the other with an olive/sunflower (O/SO) mixture (rich in α-tocopherol). Effects on γ-carboxylation were assessed from coagulation assays and sensitive assays for undercarboxylated prothrombin (ucFII) and osteocalcin (ucOC). Total plasma matrix Gla-protein (MGP) was also measured. After an initial adjustment diet, 26 healthy young men were fed, in a crossover design, the O/SO or CO diet for 2 weeks. Mean intakes of K₁ during consumption of adjustment, O/SO, and CO diets were 225 μg/day, 291 μg/day, and 291 μg/day, respectively. Mean fasting levels of TAG and K₁ were both significantly reduced by the CO diet, but not by the O/SO diet. Neither diet reduced FII activity but ucFII became detectable in nine subjects, eight of whom showed this abnormality with both diets. The CO diet induced a rise in ucOC (P < 0.05), which was negatively correlated to ucFII (r = -0.71, P < 0.03). The CO but not O/SO diet induced a decrease of total circulating MGP. We conclude that both oils, notably CO, affected vitamin K absorption and/or metabolism which may increase the requirements for γ-carboxylation. The mechanism is unclear but may result from interactions of vitamin K with PUFA and/or other lipid components such as vitamin E.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Universitätsklinikum Maastricht, St. Thomas' Hospital

Journal

Journal of Lipid Research

Band

43

Seiten

878-884

Anzahl der Seiten

7

ISSN

0022-2275

Publikationsdatum

2002

Peer-reviewed

Ja

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Biochemistry, Endocrinology, Cell Biology

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/novel-effects-of-diets-enriched-with-corn-oil-or-with-an-olive-oilsunflower-oil-mixture-on-vitamin-k-metabolism-and-vitamin-kdependent-proteins-in-young-men(4fd4004a-4c19-4764-817b-a92fd1fc1a17).html