Serum bilirubin levels and risk of colorectal cancer in Korean adults
- Autor(en)
- Hwayoung Noh, Jeeyoo Lee, Nazlisadat Seyed Khoei, Laia Peruchet-Noray, Daehee Kang, Beatrice Fervers, Karl-Heinz Wagner, Aesun Shin, Heinz Freisling
- Abstrakt
BACKGROUND: Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent.
METHODS: In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CRC risk in 78,467 Korean adults aged 40-78 years at recruitment, considering potential non-linearity and sex differences. Hazard ratios (HR) and 95% confidence intervals (CI) for associations with CRC risk were estimated with Cox proportional hazard regression.
RESULTS: During a median 7.9-year follow-up, 539 incident CRC cases were recorded. In multivariable-adjusted models, higher levels of total bilirubin were associated with a 26% (CI: 42% to 7%) lower risk of CRC among men and women combined, comparing the highest with the lowest tertile (P-linear trend = 0.003). A U-shaped association was observed in men, with the lowest risk at approximately 0.8 mg/dL (=13.7 μmol/L) of total bilirubin (P for non-linearity = 0.01). Although the association was largely null in women, there was no evidence for effect modification by sex (P-interaction = 0.73). Associations between indirect bilirubin and CRC risk were similar.
CONCLUSIONS: Higher circulating levels of total and indirect bilirubin were inversely associated with the risk of CRC among Korean adults. The associations were strongly inverse and U-shaped among men.
- Organisation(en)
- Department für Ernährungswissenschaften
- Externe Organisation(en)
- Department Cancer Environment Center Léon Bérard, International Agency for Research on Cancer (IARC-WHO), Seoul National University College of Medicine, Universitat de Barcelona, Seoul National University (SNU)
- Journal
- British Journal of Cancer
- Band
- 131
- Seiten
- 1635-1643
- Anzahl der Seiten
- 9
- ISSN
- 0007-0920
- DOI
- https://doi.org/10.1038/s41416-024-02847-9
- Publikationsdatum
- 2024
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303009 Ernährungswissenschaften
- ASJC Scopus Sachgebiete
- Oncology, Cancer Research
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/553c1a83-29cf-43ec-a313-b9e0856531d9