Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Changes the Composition of the Oral, But Not the Intestinal Microbiome
- Autor(en)
- Rebeka Fejes, Joana Séneca, Petra Pjevac, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Romy Steiner, Karl Heinz Wagner, Richard J. Woodman, Catherine P. Bondonno, Jonathan M. Hodgson, David Berry, Michael Wolzt, Oliver Neubauer
- Abstrakt
Inorganic dietary nitrate, metabolized through an endogenous pathway involving nitrate reducing bacteria, improves cardiovascular health, but its effects on the oral and intestinal microbiomes of older adults with treated hypertension are unknown. Our study investigated the effects of nitrate from beetroot juice on the oral and intestinal microbiomes of this population. A randomized, double-blind, placebo-controlled crossover trial was conducted with 15 participants (age range: 56–71 years), who consumed nitrate-rich or nitrate-depleted (placebo) beetroot juice for 4 weeks. The oral microbiome analysis revealed an increase in Neisseria and a decrease in Veillonella relative abundance (for both, PERMANOVA p < 0.001), with no significant changes in the intestinal microbiome composition. Our findings suggest that an increased dietary nitrate intake from a vegetable source may selectively modulate the oral microbiome and promote an increased abundance of nitrate-reducing species, which was previously associated with improved cardiovascular health outcomes.
- Organisation(en)
- Department für Ernährungswissenschaften, Department für Mikrobiologie und Ökosystemforschung
- Externe Organisation(en)
- Medizinische Universität Wien, Flinders University, Edith Cowan University, Universität für Weiterbildung Krems
- Journal
- Molecular Nutrition and Food Research
- Anzahl der Seiten
- 8
- ISSN
- 1613-4125
- DOI
- https://doi.org/10.1002/mnfr.70156
- Publikationsdatum
- 06-2025
- Peer-reviewed
- Ja
- ÖFOS 2012
- 106022 Mikrobiologie, 106059 Mikrobiomforschung
- Schlagwörter
- ASJC Scopus Sachgebiete
- Biotechnology, Food Science
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/74070175-16c4-4566-9c7e-3f76eb4e212c