Effects of dietary nitrate on inflammation and immune function, and implications for cardiovascular health

Autor(en)
Kyle Raubenheimer, Catherine Bondonno, Lauren Blekkenhorst, Karl Heinz Wagner, Jonathan M. Peake, Oliver Neubauer
Abstrakt

Inorganic dietary nitrate, found abundantly in green leafy and some root vegeta- bles, elicits several beneficial physiological effects, including a reduction in blood pressure and improvements in blood flow through nitrate–nitrite–nitric oxide sig- naling. Recent animal and human studies have shown that dietary nitrate and ni- trite also modulate inflammatory processes and immune cell function and pheno- types. Chronic low-grade inflammation and immune dysfunction play a critical role in cardiovascular disease. This review outlines the current evidence on the efficacy of nitrate-rich plant foods and other sources of dietary nitrate and nitrite to coun- teract inflammation and promote homeostasis of the immune and vascular systems. The data from these studies suggest that immune cells and immune– vasculature interactions are important targets for dietary interventions aimed at improving, preserving, or restoring cardiovascular health.

Organisation(en)
Department für Ernährungswissenschaften
Externe Organisation(en)
Edith Cowan University, Queensland University of Technology, School of Biomedical Sciences
Journal
Nutrition Reviews
Band
77
Seiten
584-599
Anzahl der Seiten
16
ISSN
0029-6643
DOI
https://doi.org/10.1093/nutrit/nuz025
Publikationsdatum
2019
Peer-reviewed
Ja
ÖFOS 2012
303009 Ernährungswissenschaften
Schlagwörter
ASJC Scopus Sachgebiete
Allgemeine Medizin
Sustainable Development Goals
SDG 3 – Gesundheit und Wohlergehen
Link zum Portal
https://ucrisportal.univie.ac.at/de/publications/765f7378-026d-4d7a-9012-9f945d7eeba4