Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules
- Autor(en)
- Christine Hoelzl, Siegfried Knasmüller, Karl-Heinz Wagner, Leonilla Elbling, Wolfgang Huber, Nina Kager, Franziska Ferk, Veronika Ehrlich, Armen Nersesyan, Oliver Neubauer, Aurelien Desmarchelier, Maricel Marin-Kuan, Thierry Delatour, Clotilde Verguet, Claudine Bezencon, Amelie Besson, Dominik Grathwohl, Tatjana Simic, Michael Kundi, Benoit Schilter, Christophe Cavin
- Abstrakt
Scope: Coffee is among the most frequently consumed beverages. Its consumption is inversely associated to the incidence of diseases related to reactive oxygen species; the phenomenon may be due to its antioxidant properties. Our primary objective was to investigate the impact of consumption of a coffee containing high levels of chlorogenic acids on the oxidation of proteins, DNA and membrane lipids; additionally, other redox biomarkers were monitored in an intervention trial.
Methods and results: The treatment group (n = 36) consumed instant coffee co-extracted from green and roasted beans, whereas the control consumed water (800 mL/P/day, 5 days). A global statistical analysis of four main biomarkers selected as primary outcomes showed that the overall changes are significant. 8-Isoprostaglandin F2 alpha in urine declined by 15.3%, 3-nitrotyrosine was decreased by 16.1%, DNA migration due to oxidized purines and pyrimidines was (not significantly) reduced in lymphocytes by 12.5 and 14.1%. Other markers such as the total antioxidant capacity were moderately increased; e.g. LDL and malondialdehyde were shifted towards a non-significant reduction.
Conclusion: The oxidation of DNA, lipids and proteins associated with the incidence of various diseases and the protection against their oxidative damage may be indicative for beneficial health effects of coffee.
- Organisation(en)
- Department für Ernährungswissenschaften
- Externe Organisation(en)
- Medizinische Universität Wien, Nestlé Research Center, University of Belgrade
- Journal
- Molecular Nutrition & Food Research
- Band
- 54
- Seiten
- 1722-1733
- Anzahl der Seiten
- 12
- ISSN
- 1613-4125
- DOI
- https://doi.org/10.1002/mnfr.201000048
- Publikationsdatum
- 2010
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303009 Ernährungswissenschaften, 301904 Krebsforschung
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/instant-coffee-with-high-chlorogenic-acid-levels-protects-humans-against-oxidative-damage-of-macromolecules(87a5176e-f092-4a38-b821-48c305da0745).html