Age and the effect of exercise, nutrition and cognitive training on oxidative stress - the Vienna Active Aging Study (VAAS), a randomized controlled trial

Autor(en)

Bernhard Franzke, Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Anela Tosevska, Trine Henriksen, Henrik E Poulsen, Eva-Maria Strasser, Barbara Wessner, Karl-Heinz Wagner

Abstrakt

The purpose of this study was to investigated the effect of age – over or under life-expectancy (LE) – on six months resistance training alone or combined with a nutritional supplement, and cognitive training by analyzing markers for oxidative stress and antioxidant defense in institutionalized elderly, living in Vienna.
Three groups (n = 117, age = 83.1 ± 6.1 years) – resistance training (RT), RT combined with protein and vitamin supplementation (RTS) or cognitive training (CT) – performed two guided training sessions per week for six months. Oxidative stress, antioxidant defense and DNA strand breaks were analyzed and transformed into an “antioxidant factor” to compare the total effect of the intervention. Physical fitness was assessed by the 6-min-walking, the chair-rise and the handgrip strength tests.
We observed significant negative baseline correlations between 8-oxo-7.8-dihydroguanosine and handgrip strength (r = −0.350, p = 0.001), and between high sensitive troponin-T and the 6-min-walking test (r = −0.210, p = 0.035). RT and RTS groups, showed significant improvements in physical performance. Over LE, subjects of the RT group demonstrated a significant greater response in the “antioxidant factor” compared to RTS and CT (RT vs. RTS p = 0.033, RT vs. CT p = 0.028), whereas no difference was observed between the intervention groups under LE.
Six months of elastic band resistance training lead to improvements in antioxidant defense, DNA stability and oxidative damage, summarized in the “antioxidant factor”, however mainly in subjects over their statistical LE. Consuming a supplement containing antioxidants might inhibit optimal cellular response to exercise.

Organisation(en)

Institut für Sport- und Bewegungswissenschaft, Department für Ernährungswissenschaften

Externe Organisation(en)

Rigshospitalet, Sozialmedizinisches Zentrum Süd – Kaiser-Franz-Josef-Spital

Journal

Free Radical Biology & Medicine

Band

121

Seiten

69-77

Anzahl der Seiten

9

ISSN

0891-5849

DOI

https://doi.org/10.1016/j.freeradbiomed.2018.04.565

Publikationsdatum

04-2018

Peer-reviewed

Ja

ÖFOS 2012

303028 Sportwissenschaft, 303009 Ernährungswissenschaften, 302020 Gerontologie

Schlagwörter

ASJC Scopus Sachgebiete

Physiology (medical), Biochemistry

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/b4524b4a-7390-4b55-a9b7-2ad72a2217f3