The effect of six months of elastic band resistance training, nutritional supplementation or cognitive training on chromosomal damage in institutionalized elderly
- Autor(en)
- Bernhard Franzke, Barbara Halper, Marlene Hofmann, Stefan Oesen, Beatrice Pierson, Ariane Cremer, Evelyn Bacher, Birgit Fuchs, Andreas Baierl, Anela Tosevska, Eva-Maria Strasser, Barbara Wessner, Karl-Heinz Wagner,
- Abstrakt
Increased DNA and chromosomal damage are linked to aging and age-related diseases like cardiovascular diseases, diabetes or cancer. Physical activity and an optimal status of micro- and macronutrients are known to reduce the incidence of MN, a marker for chromosomal instability and mutagenicity. Once older people reach a certain age they change from a home-living situation to an institutionalized situation, which is often accompanied by malnutrition, depression and inactivity. We conducted the current study to investigate the effect of a six month progressive resistance training (RT), with or without protein and vitamin supplementation (RTS) or cognitive training (CT) only, on chromosomal damage measured by the cytokinesis block micronucleus cytome assay in 97 Austrian institutionalized women and men (65-98. years). All three intervention groups demonstrated a tendency of a reduced frequency of cells with MN (- 15%) as well as for the total number of MN (- 20%), however no significant time-effect was observed. Besides a significant increase in plasma B12 and red blood cell folate status, the six month change of B12 was negatively correlated with the six month change of the MN frequency in the RTS group (r = - 0.584, p = 0.009). Our results suggest that in this age group either physical or cognitive training may result in similar biochemical changes and therefore enhance resistance against genomic instability. Supplementation with the vitamins B12 and folic acid could contribute to reduced chromosomal damage in institutionalized elderly.
- Organisation(en)
- Forschungsplattform Active Ageing, Department für Ernährungswissenschaften, Institut für Statistik und Operations Research, Institut für Sport- und Bewegungswissenschaft
- Externe Organisation(en)
- Sozialmedizinisches Zentrum Süd – Kaiser-Franz-Josef-Spital
- Journal
- Experimental Gerontology
- Band
- 65
- Seiten
- 16-22
- Anzahl der Seiten
- 7
- ISSN
- 0531-5565
- DOI
- https://doi.org/10.1016/j.exger.2015.03.001
- Publikationsdatum
- 05-2015
- Peer-reviewed
- Ja
- ÖFOS 2012
- 303028 Sportwissenschaft, 106023 Molekularbiologie, 303009 Ernährungswissenschaften, 302020 Gerontologie
- Schlagwörter
- ASJC Scopus Sachgebiete
- Genetics, Endocrinology, Ageing, Molecular Biology, Biochemistry, Cell Biology
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen, SDG 2 – Kein Hunger
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/the-effect-of-six-months-of-elastic-band-resistance-training-nutritional-supplementation-or-cognitive-training-on-chromosomal-damage-in-institutionalized-elderly(d7038a65-f7bf-40ec-ba14-8e9f3a54f817).html