Bilirubin Metabolism Does Not Influence Serum Bile Acid Profiles According to LC-MS

Autor(en)

Tamara Christina Stelzer, Ralf Krüger, Paola Gloria Ferrario, Christine Mölzer, Marlies Wallner, Rodrig Marculescu, Daniel Doberer, Andrew Cameron Bulmer, Karl-Heinz Wagner

Abstrakt

In addition to their role in lipid absorption, bile acids (BAs) are also known for several relevant (endocrine) activities including contributing to the regulation of energy homeostasis and some non-communicable diseases (NCDs). Furthermore, moderately elevated unconjugated bilirubin levels, as observed in Gilbert's syndrome (GS), may protect against NCDs. We therefore hypothesized that the BA profile in GS subjects differs from that of normo-bilirubinemic individuals. To test this, we performed a human case-control study, in which GS (

n = 60) and controls (

n = 60) were matched for age and gender, and serum BA concentrations were measured by liquid-chromatography mass spectrometry (LC-MS). Despite analyzing a comprehensive panel of BAs, no significant differences between the two groups were observed. These data suggest that bile acid concentrations are similar between groups, indicating that altered bilirubin metabolism unlikely influences their transport into the blood.

Organisation(en)

Department für Ernährungswissenschaften

Externe Organisation(en)

Universität Hamburg, Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), Max Rubner-Institut - Bundesforschungsinstitut für Ernährung und Lebensmittel, Medizinische Universität Wien, Fachhochschule Joanneum, Klinik Floridsdorf, Griffith University

Journal

International Journal of Molecular Sciences

Band

ISSN

1422-0067

DOI

https://doi.org/10.3390/ijms26062475

Publikationsdatum

03-2025

Peer-reviewed

ÖFOS 2012

303009 Ernährungswissenschaften

Schlagwörter

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/939254d4-ceb2-4941-b627-e27f5def2070