Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and `inflammaging

Autor(en)
Annette Brandt, Anja Baumann, Angélica Hernández-Arriaga, Finn Jung, Anika Nier, Raphaela Staltner, Dragana Rajcic, Christian Schmeer, Otto W. Witte, Barbara Wessner, Bernhard Franzke, Karl-Heinz Wagner, Amelia Camarinha-Silva, Ina Bergheim
Abstrakt

Aging is considered a state of low grade inflammation, occurring in the absence of any overt infection often referred to as ‘inflammaging'. Maintaining intestinal homeostasis may be a target to extend a healthier status in older adults. Here, we report that even in healthy older men low grade bacterial endotoxemia is prevalent. In addition, employing multiple mouse models, we also show that while intestinal microbiota composition changes significantly during aging, fecal microbiota transplantation to old mice does not protect against aging-associated intestinal barrier dysfunction in small intestine. Rather, intestinal NO homeostasis and arginine metabolism mediated through arginase and NO synthesis is altered in small intestine of aging mice. Treatment with the arginase inhibitor norNOHA prevented aging-associated intestinal barrier dysfunction, low grade endotoxemia and delayed the onset of senescence in peripheral tissue e.g., liver. Intestinal arginine and NO metabolisms could be a target in the prevention of aging-associated intestinal barrier dysfunction and subsequently decline and ‘inflammaging'.

Organisation(en)
Department für Ernährungswissenschaften, Institut für Sport- und Bewegungswissenschaft
Externe Organisation(en)
Universität Hohenheim, Universitätsklinikum Jena
Journal
Redox biology
Band
58
ISSN
2213-2317
DOI
https://doi.org/10.1016/j.redox.2022.102528
Publikationsdatum
12-2022
Peer-reviewed
Ja
ÖFOS 2012
303009 Ernährungswissenschaften
Schlagwörter
ASJC Scopus Sachgebiete
Clinical Biochemistry, Organic Chemistry
Link zum Portal
https://ucrisportal.univie.ac.at/de/publications/impairments-of-intestinal-arginine-and-no-metabolisms-trigger-agingassociated-intestinal-barrier-dysfunction-and-inflammaging(b12480f8-2e45-4c3b-af39-722ab0b0c4bd).html